Elevated gamma-glutamyl transferase (ggt) after Tramadol in dogs

The FDA has received 69 reports of elevated gamma-glutamyl transferase (ggt) in dogs after Tramadol. That is 1.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

69Reports
70%Marked serious
12%Recovered
35%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
6 12%
1–2 days
2 4.0%
3–7 days
11 22%
1–4 weeks
16 32%
Over a month
15 30%

How the animals did

Recovered
8 12%
Still unwell when reported
22 32%
Died
5 7.2%
Euthanised
19 28%
Not known
15 22%

Problems reported at the same time

Liver problems
67 97%
Loss of appetite
45 65%
Vomiting
44 64%
Lethargy
31 45%
Death
24 35%
Leucocytosis
21 30%
Abnormal ultrasound finding
20 29%
Diarrhea
20 29%

Age of the animals

Under 1 year
3
1–3 years
2
4–7 years
15
8–11 years
24
12+ years
25

About this medicine

Type: medicine.

Questions owners ask

Can Tramadol cause elevated gamma-glutamyl transferase (ggt) in dogs?
69 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Tramadol in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)