Elevated gamma-glutamyl transferase (ggt) after Melarsomine (Immiticide) in dogs

The FDA has received 119 reports of elevated gamma-glutamyl transferase (ggt) in dogs after Melarsomine. That is 0.5% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

119Reports

64%Marked serious

8.4%Recovered

9.2%Died or euthanised

11 daysTypical onset

How soon it started

Same day

6 6.6%

1–2 days

4 4.4%

3–7 days

27 30%

1–4 weeks

22 24%

Over a month

32 35%

How the animals did

Recovered

10 8.4%

Still unwell when reported

38 32%

Died

5 4.2%

Euthanised

6 5.0%

Not known

60 50%

Problems reported at the same time

116 97%

68 57%

49 41%

41 34%

36 30%

27 23%

23 19%

19 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause elevated gamma-glutamyl transferase (ggt) in dogs?: 119 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

Elevated gamma-glutamyl transferase (ggt) after Polysulfated Glycosaminoglycan 52 reports · 1.0% of its reports
Elevated gamma-glutamyl transferase (ggt) after Diphenhydramine 46 reports · 1.0% of its reports
Elevated gamma-glutamyl transferase (ggt) after Butorphanol 44 reports · 1.0% of its reports
Elevated gamma-glutamyl transferase (ggt) after Cefpodoxime 42 reports · 1.0% of its reports
Elevated gamma-glutamyl transferase (ggt) after Tramadol 69 reports · 1.8% of its reports
Elevated gamma-glutamyl transferase (ggt) after Desoxycorticosterone Pivalate 26 reports · 0.8% of its reports
Elevated gamma-glutamyl transferase (ggt) after Dirlotapide 22 reports · 0.8% of its reports
Elevated gamma-glutamyl transferase (ggt) after Isoflurane 26 reports · 0.9% of its reports
Elevated gamma-glutamyl transferase (ggt) after Famotidine 63 reports · 2.4% of its reports
Elevated gamma-glutamyl transferase (ggt) after Chondroitin + Glucosamine 53 reports · 2.0% of its reports

All reported side effects of Melarsomine in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)