Elevated gamma-glutamyl transferase (ggt) after Famotidine in dogs

The FDA has received 63 reports of elevated gamma-glutamyl transferase (ggt) in dogs after Famotidine. That is 2.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

63Reports
75%Marked serious
7.9%Recovered
40%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
6 12%
1–2 days
4 7.8%
3–7 days
7 14%
1–4 weeks
18 35%
Over a month
16 31%

How the animals did

Recovered
5 7.9%
Still unwell when reported
24 38%
Died
7 11%
Euthanised
18 29%
Not known
9 14%

Problems reported at the same time

Liver problems
61 97%
Loss of appetite
43 68%
Vomiting
38 60%
Lethargy
36 57%
Death
24 38%
Kidney problems
23 37%
Abnormal ultrasound finding
17 27%
Leucocytosis
17 27%

Age of the animals

Under 1 year
1
1–3 years
11
4–7 years
14
8–11 years
23
12+ years
14

About this medicine

Type: medicine.

Questions owners ask

Can Famotidine cause elevated gamma-glutamyl transferase (ggt) in dogs?
63 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Famotidine in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)