Leucocytosis after Tramadol in dogs

The FDA has received 162 reports of leucocytosis in dogs after Tramadol. That is 4.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

162Reports
78%Marked serious
8.6%Recovered
43%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
21 16%
1–2 days
21 16%
3–7 days
30 23%
1–4 weeks
27 20%
Over a month
33 25%

How the animals did

Recovered
13 8.0%
Recovered with lasting effects
1 0.6%
Still unwell when reported
66 41%
Died
21 13%
Euthanised
49 30%
Not known
12 7.4%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
21
4–7 years
43
8–11 years
66
12+ years
29

About this medicine

Type: medicine.

Questions owners ask

Can Tramadol cause leucocytosis in dogs?
162 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

All reported side effects of Tramadol in dogs · Medicines most reported with leucocytosis