Leucocytosis after Polysulfated Glycosaminoglycan in dogs

The FDA has received 97 reports of leucocytosis in dogs after Polysulfated Glycosaminoglycan. That is 1.8% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

97Reports
60%Marked serious
5.2%Recovered
43%Died or euthanised
20 daysTypical onset
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How soon it started

Same day
10 22%
1–2 days
0 0.0%
3–7 days
6 13%
1–4 weeks
12 27%
Over a month
17 38%

How the animals did

Recovered
5 5.2%
Still unwell when reported
19 20%
Died
20 21%
Euthanised
22 23%
Not known
31 32%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
8
4–7 years
22
8–11 years
38
12+ years
28

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause leucocytosis in dogs?
97 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 20 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with leucocytosis