Leucocytosis after Butorphanol in dogs

The FDA has received 115 reports of leucocytosis in dogs after Butorphanol. That is 2.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

115Reports
65%Marked serious
11%Recovered
41%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
27 31%
1–2 days
21 24%
3–7 days
12 14%
1–4 weeks
16 18%
Over a month
12 14%

How the animals did

Recovered
13 11%
Still unwell when reported
29 25%
Died
27 23%
Euthanised
20 17%
Not known
26 23%

Problems reported at the same time

Age of the animals

Under 1 year
12
1–3 years
19
4–7 years
27
8–11 years
42
12+ years
14

About this medicine

Type: medicine.

Questions owners ask

Can Butorphanol cause leucocytosis in dogs?
115 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

All reported side effects of Butorphanol in dogs · Medicines most reported with leucocytosis