Leucocytosis after Melarsomine (Immiticide) in dogs

The FDA has received 457 reports of leucocytosis in dogs after Melarsomine. That is 2.0% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

457Reports

42%Marked serious

5.5%Recovered

13%Died or euthanised

8 daysTypical onset

How soon it started

Same day

20 8.6%

1–2 days

43 18%

3–7 days

45 19%

1–4 weeks

43 18%

Over a month

82 35%

How the animals did

Recovered

22 4.8%

Recovered with lasting effects

3 0.7%

Still unwell when reported

118 26%

Died

47 10%

Euthanised

11 2.4%

Not known

256 56%

Problems reported at the same time

207 45%

190 42%

183 40%

138 30%

129 28%

123 27%

100 22%

95 21%

Age of the animals

Under 1 year

1–3 years

173

4–7 years

182

8–11 years

12+ years

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause leucocytosis in dogs?: 457 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

Leucocytosis after Polysulfated Glycosaminoglycan 97 reports · 1.8% of its reports
Leucocytosis after Diphenhydramine 159 reports · 3.4% of its reports
Leucocytosis after Butorphanol 115 reports · 2.6% of its reports
Leucocytosis after Cefpodoxime 138 reports · 3.4% of its reports
Leucocytosis after Tramadol 162 reports · 4.3% of its reports
Leucocytosis after Florfenicol + Mometasone + Terbinafine 31 reports · 0.9% of its reports
Leucocytosis after Desoxycorticosterone Pivalate 89 reports · 2.7% of its reports
Leucocytosis after Propofol 81 reports · 2.6% of its reports
Leucocytosis after Dirlotapide 53 reports · 1.9% of its reports
Leucocytosis after Isoflurane 88 reports · 3.2% of its reports

All reported side effects of Melarsomine in dogs · Medicines most reported with leucocytosis