Liver problems after S-adenosylmethionine in dogs

The FDA has received 120 reports of liver problems in dogs after S-adenosylmethionine. That is 31% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Type: medicine.

Questions owners ask

Can S-adenosylmethionine cause liver problems in dogs?

120 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 38 days of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

• Liver problems after Melarsomine (Immiticide) 1,315 reports · 5.8% of its reports
• Liver problems after Polysulfated Glycosaminoglycan 548 reports · 10% of its reports
• Liver problems after Diphenhydramine 500 reports · 11% of its reports
• Liver problems after Butorphanol 371 reports · 8.4% of its reports
• Liver problems after Cefpodoxime 475 reports · 12% of its reports
• Liver problems after Tramadol 684 reports · 18% of its reports
• Liver problems after Florfenicol + Mometasone + Terbinafine 133 reports · 3.8% of its reports
• Liver problems after Desoxycorticosterone Pivalate 276 reports · 8.3% of its reports
• Liver problems after Propofol 201 reports · 6.5% of its reports
• Liver problems after Dirlotapide 284 reports · 10% of its reports

All reported side effects of S-adenosylmethionine in dogs · Medicines most reported with liver problems