Lethargy after S-adenosylmethionine in dogs

76 reports to the FDA describe lethargy in dogs given S-adenosylmethionine. That is 19% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

76Reports
53%Marked serious
32%Recovered
21%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
7 14%
1–2 days
7 14%
3–7 days
3 6.0%
1–4 weeks
7 14%
Over a month
26 52%

How the animals did

Recovered
20 26%
Recovered with lasting effects
4 5.3%
Still unwell when reported
29 38%
Died
5 6.6%
Euthanised
11 14%
Not known
7 9.2%

Problems reported at the same time

41 54%
21 28%
17 22%
Abnormal radiograph finding
11 14%

Age of the animals

Under 1 year
1
1–3 years
6
4–7 years
10
8–11 years
26
12+ years
32

About this medicine

Type: medicine.

Questions owners ask

Can S-adenosylmethionine cause lethargy in dogs?
76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of S-adenosylmethionine in dogs · Medicines most reported with lethargy