Death after S-adenosylmethionine in dogs

49 reports to the FDA describe death in dogs given S-adenosylmethionine. That is 13% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

49Reports
100%Marked serious
0.0%Recovered
98%Died or euthanised
9 daysTypical onset
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How soon it started

Same day
3 8.3%
1–2 days
9 25%
3–7 days
5 14%
1–4 weeks
7 19%
Over a month
12 33%

How the animals did

Still unwell when reported
1 2.0%
Died
18 37%
Euthanised
30 61%

Problems reported at the same time

19 39%
17 35%
Blood problems
11 22%
Abnormal radiograph finding
8 16%

Age of the animals

Under 1 year
1
1–3 years
3
4–7 years
5
8–11 years
19
12+ years
21

About this medicine

Type: medicine.

Questions owners ask

Can S-adenosylmethionine cause death in dogs?
49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 9 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

All reported side effects of S-adenosylmethionine in dogs · Medicines most reported with death