Kidney problems after S-adenosylmethionine in dogs

33 reports to the FDA describe kidney problems in dogs given S-adenosylmethionine. That is 8.4% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

33Reports
70%Marked serious
3.0%Recovered
39%Died or euthanised
55 daysTypical onset
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How soon it started

Same day
0 0.0%
1–2 days
2 9.5%
3–7 days
3 14%
1–4 weeks
5 24%
Over a month
11 52%

How the animals did

Recovered with lasting effects
1 3.0%
Still unwell when reported
14 42%
Died
5 15%
Euthanised
8 24%
Not known
5 15%

Problems reported at the same time

13 39%
11 33%
11 33%
10 30%
Blood problems
7 21%

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
4
8–11 years
9
12+ years
16

About this medicine

Type: medicine.

Questions owners ask

Can S-adenosylmethionine cause kidney problems in dogs?
33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 55 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

All reported side effects of S-adenosylmethionine in dogs · Medicines most reported with kidney problems