Seizures after S-adenosylmethionine in dogs

25 reports to the FDA describe seizures in dogs given S-adenosylmethionine. That is 6.4% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

25Reports
76%Marked serious
48%Recovered
32%Died or euthanised
72 daysTypical onset
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How soon it started

Same day
2 11%
1–2 days
1 5.6%
3–7 days
3 17%
1–4 weeks
1 5.6%
Over a month
11 61%

How the animals did

Recovered
10 40%
Recovered with lasting effects
2 8.0%
Still unwell when reported
2 8.0%
Died
5 20%
Euthanised
3 12%
Not known
3 12%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
2
4–7 years
1
8–11 years
10
12+ years
11

About this medicine

Type: medicine.

Questions owners ask

Can S-adenosylmethionine cause seizures in dogs?
25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 72 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

All reported side effects of S-adenosylmethionine in dogs · Medicines most reported with seizures