Retching after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 77 reports of retching in dogs after Pyrantel + Sarolaner. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

77Reports
45%Marked serious
27%Recovered
6.5%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
43 59%
1–2 days
17 23%
3–7 days
3 4.1%
1–4 weeks
4 5.5%
Over a month
6 8.2%

How the animals did

Recovered
21 27%
Still unwell when reported
28 36%
Died
3 3.9%
Euthanised
2 2.6%
Not known
23 30%

Problems reported at the same time

Vomiting
47 61%
Lethargy
33 43%
Loss of appetite
26 34%
Diarrhea
21 27%
Tremors
16 21%
Breathing problems
11 14%
Behaviour change
9 12%
Seizures
9 12%

Age of the animals

Under 1 year
20
1–3 years
29
4–7 years
11
8–11 years
10
12+ years
4

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause retching in dogs?
77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Retching with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with retching