Adipsia after Pyrantel + Sarolaner (Simparica Trio) in dogs

99 reports to the FDA describe adipsia in dogs given Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

99Reports
51%Marked serious
23%Recovered
12%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
39 41%
1–2 days
40 42%
3–7 days
10 11%
1–4 weeks
3 3.2%
Over a month
3 3.2%

How the animals did

Recovered
23 23%
Still unwell when reported
32 32%
Died
3 3.0%
Euthanised
9 9.1%
Not known
32 32%

Problems reported at the same time

Age of the animals

Under 1 year
21
1–3 years
32
4–7 years
20
8–11 years
12
12+ years
14

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause adipsia in dogs?
99 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Adipsia with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with adipsia