Adipsia after Praziquantel + Pyrantel in dogs

The FDA has received 26 reports of adipsia in dogs after Praziquantel + Pyrantel. That is 0.7% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

58%Marked serious

15%Recovered

12%Died or euthanised

1 daysTypical onset

How soon it started

Same day

8 47%

1–2 days

9 53%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

0 0.0%

How the animals did

Recovered

4 15%

Still unwell when reported

2 7.7%

Died

2 7.7%

Euthanised

1 3.8%

Not known

17 65%

Problems reported at the same time

25 96%

16 62%

14 54%

11 42%

4 15%

Digestive tract disorder

3 12%

Weakness

3 12%

Tremors

2 7.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause adipsia in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Adipsia with similar medicines

Adipsia after Pyrantel + Sarolaner (Simparica Trio) 99 reports · 0.2% of its reports
Adipsia after Febantel + Praziquantel + Pyrantel (Drontal Plus) 53 reports · 0.8% of its reports
Adipsia after Fenbendazole 102 reports · 1.7% of its reports
Adipsia after Pyrantel 82 reports · 1.7% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with adipsia