Digestive tract disorder after Praziquantel + Pyrantel in dogs

The FDA has received 56 reports of digestive tract disorder in dogs after Praziquantel + Pyrantel. That is 1.5% of all reports for this medicine, compared with 2.0% across reports for all dog medicines.

56Reports
27%Marked serious
21%Recovered
11%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
19 58%
1–2 days
8 24%
3–7 days
2 6.1%
1–4 weeks
0 0.0%
Over a month
4 12%

How the animals did

Recovered
12 21%
Still unwell when reported
2 3.6%
Died
4 7.1%
Euthanised
2 3.6%
Not known
36 64%

Problems reported at the same time

Age of the animals

Under 1 year
23
1–3 years
13
4–7 years
6
8–11 years
4
12+ years
5

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause digestive tract disorder in dogs?
56 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Digestive tract disorder with similar medicines

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with digestive tract disorder