Restlessness or agitation after Polysulfated Glycosaminoglycan in dogs

The FDA has received 126 reports of restlessness or agitation in dogs after Polysulfated Glycosaminoglycan. That is 2.3% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

126Reports

38%Marked serious

35%Recovered

11%Died or euthanised

5 daysTypical onset

How soon it started

Same day

24 31%

1–2 days

10 13%

3–7 days

6 7.8%

1–4 weeks

15 19%

Over a month

22 29%

How the animals did

Recovered

44 35%

Still unwell when reported

22 17%

Died

6 4.8%

Euthanised

8 6.3%

Not known

46 37%

Problems reported at the same time

55 44%

38 30%

36 29%

30 24%

25 20%

23 18%

14 11%

13 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause restlessness or agitation in dogs?: 126 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Melarsomine (Immiticide) 679 reports · 3.0% of its reports
Restlessness or agitation after Diphenhydramine 167 reports · 3.5% of its reports
Restlessness or agitation after Butorphanol 130 reports · 2.9% of its reports
Restlessness or agitation after Cefpodoxime 111 reports · 2.7% of its reports
Restlessness or agitation after Tramadol 131 reports · 3.5% of its reports
Restlessness or agitation after Florfenicol + Mometasone + Terbinafine 80 reports · 2.3% of its reports
Restlessness or agitation after Desoxycorticosterone Pivalate 82 reports · 2.5% of its reports
Restlessness or agitation after Propofol 60 reports · 2.0% of its reports
Restlessness or agitation after Dirlotapide 37 reports · 1.3% of its reports
Restlessness or agitation after Isoflurane 64 reports · 2.3% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with restlessness or agitation