Restlessness or agitation after Melarsomine (Immiticide) in dogs

The FDA has received 679 reports of restlessness or agitation in dogs after Melarsomine. That is 3.0% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

679Reports

45%Marked serious

19%Recovered

5.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

259 62%

1–2 days

26 6.2%

3–7 days

11 2.6%

1–4 weeks

45 11%

Over a month

77 18%

How the animals did

Recovered

124 18%

Recovered with lasting effects

2 0.3%

Still unwell when reported

117 17%

Died

26 3.8%

Euthanised

8 1.2%

Not known

402 59%

Problems reported at the same time

226 33%

159 23%

158 23%

123 18%

Injection site reaction

107 16%

Vocalising

100 15%

Vomiting

93 14%

Loss of appetite

79 12%

Age of the animals

Under 1 year

1–3 years

321

4–7 years

237

8–11 years

12+ years

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause restlessness or agitation in dogs?: 679 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Polysulfated Glycosaminoglycan 126 reports · 2.3% of its reports
Restlessness or agitation after Diphenhydramine 167 reports · 3.5% of its reports
Restlessness or agitation after Butorphanol 130 reports · 2.9% of its reports
Restlessness or agitation after Cefpodoxime 111 reports · 2.7% of its reports
Restlessness or agitation after Tramadol 131 reports · 3.5% of its reports
Restlessness or agitation after Florfenicol + Mometasone + Terbinafine 80 reports · 2.3% of its reports
Restlessness or agitation after Desoxycorticosterone Pivalate 82 reports · 2.5% of its reports
Restlessness or agitation after Propofol 60 reports · 2.0% of its reports
Restlessness or agitation after Dirlotapide 37 reports · 1.3% of its reports
Restlessness or agitation after Isoflurane 64 reports · 2.3% of its reports

All reported side effects of Melarsomine in dogs · Medicines most reported with restlessness or agitation