Restlessness or agitation after Tramadol in dogs

The FDA has received 131 reports of restlessness or agitation in dogs after Tramadol. That is 3.5% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

131Reports
47%Marked serious
40%Recovered
12%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
28 29%
1–2 days
16 17%
3–7 days
10 10%
1–4 weeks
16 17%
Over a month
26 27%

How the animals did

Recovered
47 36%
Recovered with lasting effects
5 3.8%
Still unwell when reported
35 27%
Died
2 1.5%
Euthanised
14 11%
Not known
28 21%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
17
4–7 years
27
8–11 years
39
12+ years
40

About this medicine

Type: medicine.

Questions owners ask

Can Tramadol cause restlessness or agitation in dogs?
131 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Tramadol in dogs · Medicines most reported with restlessness or agitation