Swelling after Phenylpropanolamine (Proin) in dogs

The FDA has received 71 reports of swelling in dogs after Phenylpropanolamine. That is 1.7% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

71Reports

68%Marked serious

42%Recovered

20%Died or euthanised

1 daysTypical onset

How soon it started

Same day

20 41%

1–2 days

10 20%

3–7 days

4 8.2%

1–4 weeks

3 6.1%

Over a month

12 24%

How the animals did

Recovered

30 42%

Still unwell when reported

14 20%

Died

2 2.8%

Euthanised

12 17%

Not known

13 18%

Problems reported at the same time

19 27%

17 24%

17 24%

15 21%

14 20%

Restlessness or agitation

13 18%

Loss of appetite

11 15%

Skin redness

10 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause swelling in dogs?: 71 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Trilostane (Vetoryl) 149 reports · 1.2% of its reports
Swelling after Insulin 107 reports · 1.5% of its reports
Swelling after Levothyroxine 82 reports · 2.7% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with swelling