Skin redness after Phenylpropanolamine (Proin) in dogs

The FDA has received 212 reports of skin redness in dogs after Phenylpropanolamine. That is 5.1% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

212Reports
49%Marked serious
66%Recovered
2.4%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
111 74%
1–2 days
18 12%
3–7 days
4 2.7%
1–4 weeks
4 2.7%
Over a month
12 8.1%

How the animals did

Recovered
139 66%
Recovered with lasting effects
1 0.5%
Still unwell when reported
10 4.7%
Euthanised
5 2.4%
Not known
57 27%

Problems reported at the same time

Age of the animals

Under 1 year
22
1–3 years
60
4–7 years
56
8–11 years
51
12+ years
21

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause skin redness in dogs?
212 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with skin redness