Allergic reaction after Phenylpropanolamine (Proin) in dogs

63 reports to the FDA describe allergic reaction in dogs given Phenylpropanolamine. That is 1.5% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

63Reports
52%Marked serious
57%Recovered
3.2%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
26 59%
1–2 days
4 9.1%
3–7 days
4 9.1%
1–4 weeks
3 6.8%
Over a month
7 16%

How the animals did

Recovered
35 56%
Recovered with lasting effects
1 1.6%
Still unwell when reported
10 16%
Died
1 1.6%
Euthanised
1 1.6%
Not known
15 24%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
20
4–7 years
15
8–11 years
16
12+ years
8

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause allergic reaction in dogs?
63 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Allergic reaction with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with allergic reaction