Liver problems after Ondansetron in dogs

215 reports to the FDA describe liver problems in dogs given Ondansetron. That is 32% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

215Reports
90%Marked serious
10%Recovered
48%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
37 20%
1–2 days
36 20%
3–7 days
23 13%
1–4 weeks
39 21%
Over a month
47 26%

How the animals did

Recovered
22 10%
Still unwell when reported
73 34%
Died
26 12%
Euthanised
78 36%
Not known
16 7.4%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
37
4–7 years
71
8–11 years
68
12+ years
31

About this medicine

Type: medicine.

Questions owners ask

Can Ondansetron cause liver problems in dogs?
215 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Ondansetron in dogs · Medicines most reported with liver problems