Liver problems after Neomycin + Polymyxin B in dogs

The FDA has received 26 reports of liver problems in dogs after Neomycin + Polymyxin B. That is 13% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports
85%Marked serious
0.0%Recovered
23%Died or euthanised
30 daysTypical onset
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How soon it started

Same day
3 14%
1–2 days
2 9.1%
3–7 days
3 14%
1–4 weeks
5 23%
Over a month
9 41%

How the animals did

Still unwell when reported
9 35%
Died
2 7.7%
Euthanised
4 15%
Not known
11 42%

Problems reported at the same time

10 38%
Skin rash or irritation
7 27%

Age of the animals

Under 1 year
1
1–3 years
2
4–7 years
7
8–11 years
11
12+ years
4

About this medicine

Type: medicine.

Questions owners ask

Can Neomycin + Polymyxin B cause liver problems in dogs?
26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 30 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Neomycin + Polymyxin B in dogs · Medicines most reported with liver problems