Lethargy after Neomycin + Polymyxin B in dogs

The FDA has received 29 reports of lethargy in dogs after Neomycin + Polymyxin B. That is 15% of all reports for this medicine, compared with 11% across reports for all dog medicines.

29Reports
79%Marked serious
14%Recovered
10%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
11 52%
1–2 days
3 14%
3–7 days
1 4.8%
1–4 weeks
2 9.5%
Over a month
4 19%

How the animals did

Recovered
3 10%
Recovered with lasting effects
1 3.4%
Still unwell when reported
8 28%
Died
1 3.4%
Euthanised
2 6.9%
Not known
14 48%

Problems reported at the same time

Corneal disorder
10 34%
Keratoconjunctivitis sicca
7 24%
Schirmer tear test
7 24%

Age of the animals

Under 1 year
1
1–3 years
5
4–7 years
7
8–11 years
9
12+ years
5

About this medicine

Type: medicine.

Questions owners ask

Can Neomycin + Polymyxin B cause lethargy in dogs?
29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Neomycin + Polymyxin B in dogs · Medicines most reported with lethargy