Corneal ulcer after Neomycin + Polymyxin B in dogs

The FDA has received 41 reports of corneal ulcer in dogs after Neomycin + Polymyxin B. That is 21% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

41Reports
88%Marked serious
9.8%Recovered
4.9%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
15 43%
1–2 days
4 11%
3–7 days
2 5.7%
1–4 weeks
8 23%
Over a month
6 17%

How the animals did

Recovered
3 7.3%
Recovered with lasting effects
1 2.4%
Still unwell when reported
16 39%
Euthanised
2 4.9%
Not known
19 46%

Problems reported at the same time

Squinting
14 34%
Corneal disorder
14 34%
Schirmer tear test
13 32%
12 29%

Age of the animals

Under 1 year
2
1–3 years
7
4–7 years
12
8–11 years
8
12+ years
12

About this medicine

Type: medicine.

Questions owners ask

Can Neomycin + Polymyxin B cause corneal ulcer in dogs?
41 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Corneal ulcer with similar medicines

All reported side effects of Neomycin + Polymyxin B in dogs · Medicines most reported with corneal ulcer