Corneal ulcer after Florfenicol + Mometasone + Terbinafine in dogs

The FDA has received 288 reports of corneal ulcer in dogs after Florfenicol + Mometasone + Terbinafine. That is 8.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

288Reports

85%Marked serious

21%Recovered

5.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

127 50%

1–2 days

60 24%

3–7 days

18 7.1%

1–4 weeks

26 10%

Over a month

21 8.3%

How the animals did

Recovered

54 19%

Recovered with lasting effects

7 2.4%

Still unwell when reported

114 40%

Died

2 0.7%

Euthanised

13 4.5%

Not known

98 34%

Problems reported at the same time

Ocular discharge

110 38%

Keratoconjunctivitis sicca

109 38%

Squinting

100 35%

Schirmer tear test

90 31%

Dry eye

85 30%

Neurogenic keratoconjunctivitis sicca (kcs)

76 26%

Loss of appetite

75 26%

Corneal disorder

74 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Florfenicol + Mometasone + Terbinafine cause corneal ulcer in dogs?: 288 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Corneal ulcer with similar medicines

Corneal ulcer after Diphenhydramine 30 reports · 0.6% of its reports
Corneal ulcer after Cefpodoxime 20 reports · 0.5% of its reports
Corneal ulcer after Tramadol 22 reports · 0.6% of its reports
Corneal ulcer after Betamethasone + Florfenicol + Terbinafine 73 reports · 3.0% of its reports
Corneal ulcer after Ketoconazole 53 reports · 2.3% of its reports
Corneal ulcer after Etodolac 22 reports · 1.2% of its reports
Corneal ulcer after Atropine 27 reports · 3.6% of its reports
Corneal ulcer after Neomycin 38 reports · 8.6% of its reports
Corneal ulcer after Neomycin + Polymyxin B 41 reports · 21% of its reports
Corneal ulcer after Tobramycin 38 reports · 32% of its reports

All reported side effects of Florfenicol + Mometasone + Terbinafine in dogs · Medicines most reported with corneal ulcer