Corneal ulcer after Betamethasone + Florfenicol + Terbinafine in dogs

The FDA has received 73 reports of corneal ulcer in dogs after Betamethasone + Florfenicol + Terbinafine. That is 3.0% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

73Reports
88%Marked serious
25%Recovered
0.0%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
12 20%
1–2 days
11 19%
3–7 days
12 20%
1–4 weeks
17 29%
Over a month
7 12%

How the animals did

Recovered
13 18%
Recovered with lasting effects
5 6.8%
Still unwell when reported
39 53%
Not known
16 22%

Problems reported at the same time

22 30%
18 25%
Blepharospasm
16 22%
Neurogenic keratoconjunctivitis sicca (kcs)
13 18%

Age of the animals

Under 1 year
2
1–3 years
15
4–7 years
27
8–11 years
18
12+ years
5

About this medicine

Type: medicine.

Questions owners ask

Can Betamethasone + Florfenicol + Terbinafine cause corneal ulcer in dogs?
73 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Corneal ulcer with similar medicines

All reported side effects of Betamethasone + Florfenicol + Terbinafine in dogs · Medicines most reported with corneal ulcer