Neurogenic keratoconjunctivitis sicca (kcs) after Florfenicol + Mometasone + Terbinafine in dogs

The FDA has received 131 reports of neurogenic keratoconjunctivitis sicca (kcs) in dogs after Florfenicol + Mometasone + Terbinafine. That is 3.7% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

131Reports

81%Marked serious

14%Recovered

6.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

49 42%

1–2 days

30 25%

3–7 days

6 5.1%

1–4 weeks

22 19%

Over a month

11 9.3%

How the animals did

Recovered

14 11%

Recovered with lasting effects

4 3.1%

Still unwell when reported

72 55%

Euthanised

9 6.9%

Not known

32 24%

Problems reported at the same time

Corneal ulcer

76 58%

Ocular discharge

52 40%

Squinting

44 34%

Eye disorder (for photophobia see 'neurological')

40 31%

Dry eye

39 30%

Schirmer tear test

38 29%

Abnormal schirmer tear test

37 28%

Vomiting

31 24%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Florfenicol + Mometasone + Terbinafine cause neurogenic keratoconjunctivitis sicca (kcs) in dogs?: 131 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neurogenic keratoconjunctivitis sicca (kcs) with similar medicines

Neurogenic keratoconjunctivitis sicca (kcs) after Ketoconazole 29 reports · 1.3% of its reports

All reported side effects of Florfenicol + Mometasone + Terbinafine in dogs · Medicines most reported with neurogenic keratoconjunctivitis sicca (kcs)