Neurogenic keratoconjunctivitis sicca (kcs) after Ketoconazole in dogs

29 reports to the FDA describe neurogenic keratoconjunctivitis sicca (kcs) in dogs given Ketoconazole. That is 1.3% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports

79%Marked serious

24%Recovered

0.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

11 48%

1–2 days

7 30%

3–7 days

3 13%

1–4 weeks

2 8.7%

Over a month

0 0.0%

How the animals did

Recovered

4 14%

Recovered with lasting effects

3 10%

Still unwell when reported

19 66%

Not known

3 10%

Problems reported at the same time

18 62%

15 52%

14 48%

11 38%

Abnormal schirmer tear test

9 31%

Dry eye

7 24%

Eye or vision problems

7 24%

Eye pain

7 24%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Ketoconazole cause neurogenic keratoconjunctivitis sicca (kcs) in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neurogenic keratoconjunctivitis sicca (kcs) with similar medicines

Neurogenic keratoconjunctivitis sicca (kcs) after Florfenicol + Mometasone + Terbinafine 131 reports · 3.7% of its reports

All reported side effects of Ketoconazole in dogs · Medicines most reported with neurogenic keratoconjunctivitis sicca (kcs)