Dry eye after Ketoconazole in dogs

28 reports to the FDA describe dry eye in dogs given Ketoconazole. That is 1.2% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

28Reports

71%Marked serious

25%Recovered

0.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

7 30%

1–2 days

10 43%

3–7 days

1 4.3%

1–4 weeks

3 13%

Over a month

2 8.7%

How the animals did

Recovered

6 21%

Recovered with lasting effects

1 3.6%

Still unwell when reported

13 46%

Not known

8 29%

Problems reported at the same time

15 54%

15 54%

10 36%

8 29%

7 25%

Nasal dryness

7 25%

Blepharospasm

7 25%

Neurogenic keratoconjunctivitis sicca (kcs)

7 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Ketoconazole cause dry eye in dogs?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dry eye with similar medicines

Dry eye after Florfenicol + Mometasone + Terbinafine 145 reports · 4.1% of its reports
Dry eye after Betamethasone + Florfenicol + Terbinafine 30 reports · 1.2% of its reports
Dry eye after Pilocarpine 27 reports · 35% of its reports

All reported side effects of Ketoconazole in dogs · Medicines most reported with dry eye