Liver problems after Midazolam in dogs

The FDA has received 154 reports of liver problems in dogs after Midazolam. That is 13% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

154Reports
84%Marked serious
12%Recovered
39%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
28 20%
1–2 days
29 21%
3–7 days
27 20%
1–4 weeks
25 18%
Over a month
29 21%

How the animals did

Recovered
17 11%
Recovered with lasting effects
1 0.6%
Still unwell when reported
58 38%
Died
23 15%
Euthanised
37 24%
Not known
18 12%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
31
4–7 years
41
8–11 years
54
12+ years
21

About this medicine

Type: medicine.

Questions owners ask

Can Midazolam cause liver problems in dogs?
154 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Midazolam in dogs · Medicines most reported with liver problems