Leucocytosis after Midazolam in dogs

The FDA has received 53 reports of leucocytosis in dogs after Midazolam. That is 4.4% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

53Reports
91%Marked serious
13%Recovered
36%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
10 20%
1–2 days
16 32%
3–7 days
9 18%
1–4 weeks
7 14%
Over a month
8 16%

How the animals did

Recovered
7 13%
Still unwell when reported
18 34%
Died
7 13%
Euthanised
12 23%
Not known
9 17%

Problems reported at the same time

Age of the animals

Under 1 year
9
1–3 years
10
4–7 years
13
8–11 years
17
12+ years
4

About this medicine

Type: medicine.

Questions owners ask

Can Midazolam cause leucocytosis in dogs?
53 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

All reported side effects of Midazolam in dogs · Medicines most reported with leucocytosis