Elevated globulins after Leptospirosis Vaccine in dogs

91 reports to the FDA describe elevated globulins in dogs given Leptospirosis Vaccine. That is 1.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

91Reports
74%Marked serious
9.9%Recovered
24%Died or euthanised
9 daysTypical onset
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How soon it started

Same day
14 19%
1–2 days
13 18%
3–7 days
7 9.7%
1–4 weeks
23 32%
Over a month
15 21%

How the animals did

Recovered
8 8.8%
Recovered with lasting effects
1 1.1%
Still unwell when reported
38 42%
Died
6 6.6%
Euthanised
16 18%
Not known
22 24%

Problems reported at the same time

Loss of appetite
61 67%
Lethargy
49 54%
Liver problems
43 47%
Blood problems
35 38%
Vomiting
35 38%
Kidney problems
31 34%
Neutrophilia
26 29%
Fever
25 27%

Age of the animals

Under 1 year
5
1–3 years
23
4–7 years
23
8–11 years
25
12+ years
13

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause elevated globulins in dogs?
91 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 9 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated globulins with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with elevated globulins