Lethargy after Leptospirosis Vaccine in dogs

The FDA has received 1,929 reports of lethargy in dogs after Leptospirosis Vaccine. That is 24% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,929Reports
67%Marked serious
28%Recovered
16%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
793 47%
1–2 days
273 16%
3–7 days
171 10%
1–4 weeks
194 12%
Over a month
248 15%

How the animals did

Recovered
529 27%
Recovered with lasting effects
7 0.4%
Still unwell when reported
840 44%
Died
149 7.7%
Euthanised
163 8.4%
Not known
241 12%

Problems reported at the same time

Age of the animals

Under 1 year
294
1–3 years
588
4–7 years
503
8–11 years
381
12+ years
150

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause lethargy in dogs?
1,929 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with lethargy