Liver problems after Leptospirosis Vaccine in dogs

The FDA has received 743 reports of liver problems in dogs after Leptospirosis Vaccine. That is 9.3% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

743Reports
79%Marked serious
10%Recovered
29%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
160 28%
1–2 days
73 13%
3–7 days
84 14%
1–4 weeks
116 20%
Over a month
147 25%

How the animals did

Recovered
77 10%
Still unwell when reported
353 48%
Died
77 10%
Euthanised
140 19%
Not known
96 13%

Problems reported at the same time

Age of the animals

Under 1 year
62
1–3 years
146
4–7 years
199
8–11 years
224
12+ years
106

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause liver problems in dogs?
743 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with liver problems