Leucocytosis after Leptospirosis Vaccine in dogs

The FDA has received 279 reports of leucocytosis in dogs after Leptospirosis Vaccine. That is 3.5% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

279Reports

80%Marked serious

10%Recovered

31%Died or euthanised

6 daysTypical onset

How soon it started

Same day

55 24%

1–2 days

35 15%

3–7 days

33 14%

1–4 weeks

43 19%

Over a month

66 28%

How the animals did

Recovered

28 10%

Still unwell when reported

118 42%

Died

38 14%

Euthanised

49 18%

Not known

46 16%

Problems reported at the same time

161 58%

152 54%

151 54%

140 50%

128 46%

121 43%

86 31%

84 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause leucocytosis in dogs?: 279 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

Leucocytosis after Rabies Vaccine 297 reports · 3.0% of its reports
Leucocytosis after Bordetella Vaccine 291 reports · 3.1% of its reports
Leucocytosis after Lyme Vaccine 76 reports · 1.1% of its reports
Leucocytosis after Distemper-parvo Vaccine 261 reports · 4.0% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with leucocytosis