Neutrophilia after Leptospirosis Vaccine in dogs

The FDA has received 239 reports of neutrophilia in dogs after Leptospirosis Vaccine. That is 3.0% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

239Reports

81%Marked serious

7.5%Recovered

30%Died or euthanised

9 daysTypical onset

How soon it started

Same day

36 19%

1–2 days

22 11%

3–7 days

36 19%

1–4 weeks

41 21%

Over a month

58 30%

How the animals did

Recovered

18 7.5%

Still unwell when reported

107 45%

Died

27 11%

Euthanised

44 18%

Not known

43 18%

Problems reported at the same time

138 58%

136 57%

131 55%

128 54%

102 43%

100 42%

88 37%

78 33%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause neutrophilia in dogs?: 239 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutrophilia with similar medicines

Neutrophilia after Rabies Vaccine 260 reports · 2.6% of its reports
Neutrophilia after Bordetella Vaccine 264 reports · 2.8% of its reports
Neutrophilia after Lyme Vaccine 64 reports · 0.9% of its reports
Neutrophilia after Distemper-parvo Vaccine 189 reports · 2.9% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with neutrophilia