Walking difficulty after Pyrantel + Sarolaner (Simparica Trio) in dogs

207 reports to the FDA describe walking difficulty in dogs given Pyrantel + Sarolaner. That is 0.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

207Reports
68%Marked serious
23%Recovered
11%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
76 39%
1–2 days
54 27%
3–7 days
19 9.6%
1–4 weeks
26 13%
Over a month
22 11%

How the animals did

Recovered
47 23%
Still unwell when reported
93 45%
Died
10 4.8%
Euthanised
13 6.3%
Not known
44 21%

Problems reported at the same time

Loss of appetite
63 30%
Seizures
62 30%
Lethargy
60 29%
Tremors
58 28%
Vomiting
57 28%
Breathing problems
25 12%
Diarrhea
24 12%
Behaviour change
23 11%

Age of the animals

Under 1 year
35
1–3 years
41
4–7 years
43
8–11 years
50
12+ years
32

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause walking difficulty in dogs?
207 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Walking difficulty with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with walking difficulty