Foaming at the mouth after Pyrantel + Sarolaner (Simparica Trio) in dogs
The FDA has received 147 reports of foaming at the mouth in dogs after Pyrantel + Sarolaner. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.
147Reports
80%Marked serious
29%Recovered
12%Died or euthanised
1 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.
Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Pyrantel + Sarolaner cause foaming at the mouth in dogs?
- 147 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 1 day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Foaming at the mouth with similar medicines
- Foaming at the mouth after Pyrantel 22 reports · 0.5% of its reports
- Foaming at the mouth after Praziquantel + Pyrantel 25 reports · 0.7% of its reports
All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with foaming at the mouth