Eye or vision problems after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 152 reports of eye or vision problems in dogs after Pyrantel + Sarolaner. That is 0.3% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

152Reports
87%Marked serious
18%Recovered
20%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
47 33%
1–2 days
35 25%
3–7 days
16 11%
1–4 weeks
23 16%
Over a month
21 15%

How the animals did

Recovered
24 16%
Recovered with lasting effects
4 2.6%
Still unwell when reported
69 45%
Died
9 5.9%
Euthanised
22 14%
Not known
24 16%

Problems reported at the same time

Age of the animals

Under 1 year
29
1–3 years
30
4–7 years
41
8–11 years
29
12+ years
14

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause eye or vision problems in dogs?
152 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eye or vision problems with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with eye or vision problems