Decreased urine concentration after Polysulfated Glycosaminoglycan in dogs

49 reports to the FDA describe decreased urine concentration in dogs given Polysulfated Glycosaminoglycan. That is 0.9% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

49Reports

57%Marked serious

10%Recovered

18%Died or euthanised

63 daysTypical onset

How soon it started

Same day

3 14%

1–2 days

0 0.0%

3–7 days

3 14%

1–4 weeks

4 18%

Over a month

12 55%

How the animals did

Recovered

2 4.1%

Recovered with lasting effects

3 6.1%

Still unwell when reported

15 31%

Died

3 6.1%

Euthanised

6 12%

Not known

20 41%

Problems reported at the same time

25 51%

19 39%

19 39%

15 31%

15 31%

14 29%

14 29%

12 24%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause decreased urine concentration in dogs?: 49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 63 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased urine concentration with similar medicines

Decreased urine concentration after Melarsomine (Immiticide) 60 reports · 0.3% of its reports
Decreased urine concentration after Diphenhydramine 31 reports · 0.7% of its reports
Decreased urine concentration after Butorphanol 29 reports · 0.7% of its reports
Decreased urine concentration after Cefpodoxime 58 reports · 1.4% of its reports
Decreased urine concentration after Tramadol 77 reports · 2.0% of its reports
Decreased urine concentration after Desoxycorticosterone Pivalate 92 reports · 2.8% of its reports
Decreased urine concentration after Dirlotapide 23 reports · 0.8% of its reports
Decreased urine concentration after Isoflurane 27 reports · 1.0% of its reports
Decreased urine concentration after Cephalexin 31 reports · 1.2% of its reports
Decreased urine concentration after Famotidine 44 reports · 1.7% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with decreased urine concentration