Decreased urine concentration after Desoxycorticosterone Pivalate in dogs

92 reports to the FDA describe decreased urine concentration in dogs given Desoxycorticosterone Pivalate. That is 2.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

92Reports
49%Marked serious
2.2%Recovered
7.6%Died or euthanised
16 daysTypical onset
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How soon it started

Same day
4 14%
1–2 days
1 3.4%
3–7 days
5 17%
1–4 weeks
6 21%
Over a month
13 45%

How the animals did

Recovered
2 2.2%
Still unwell when reported
25 27%
Died
4 4.3%
Euthanised
3 3.3%
Not known
58 63%

Problems reported at the same time

Excessive urination
59 64%
Excessive thirst
58 63%
Kidney problems
26 28%
Liver problems
23 25%
Loss of appetite
21 23%
Lethargy
21 23%
High sodium-potassium ratio (na:k ratio)
19 21%
Vomiting
18 20%

Age of the animals

Under 1 year
0
1–3 years
10
4–7 years
36
8–11 years
31
12+ years
14

About this medicine

Type: medicine.

Questions owners ask

Can Desoxycorticosterone Pivalate cause decreased urine concentration in dogs?
92 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 16 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased urine concentration with similar medicines

All reported side effects of Desoxycorticosterone Pivalate in dogs · Medicines most reported with decreased urine concentration