Decreased packed cell volume (pcv) after Polysulfated Glycosaminoglycan in dogs

46 reports to the FDA describe decreased packed cell volume (pcv) in dogs given Polysulfated Glycosaminoglycan. That is 0.8% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

46Reports
74%Marked serious
11%Recovered
35%Died or euthanised
69 daysTypical onset
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How soon it started

Same day
6 23%
1–2 days
0 0.0%
3–7 days
2 7.7%
1–4 weeks
2 7.7%
Over a month
16 62%

How the animals did

Recovered
4 8.7%
Recovered with lasting effects
1 2.2%
Still unwell when reported
19 41%
Died
4 8.7%
Euthanised
12 26%
Not known
6 13%

Problems reported at the same time

Blood problems
20 43%
Lethargy
18 39%
Loss of appetite
18 39%
Diarrhea
16 35%
Death
16 35%
Vomiting
13 28%
Pale mucous membrane
13 28%
Kidney problems
12 26%

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
4
8–11 years
21
12+ years
21

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause decreased packed cell volume (pcv) in dogs?
46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 69 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased packed cell volume (pcv) with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with decreased packed cell volume (pcv)