Decreased packed cell volume (pcv) after Ketoconazole in dogs

21 reports to the FDA describe decreased packed cell volume (pcv) in dogs given Ketoconazole. That is 0.9% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

21Reports

76%Marked serious

19%Recovered

19%Died or euthanised

111 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

1 6.7%

3–7 days

2 13%

1–4 weeks

1 6.7%

Over a month

11 73%

How the animals did

Recovered

4 19%

Still unwell when reported

9 43%

Died

1 4.8%

Euthanised

3 14%

Not known

4 19%

Problems reported at the same time

Loss of appetite

13 62%

Lethargy

11 52%

Liver problems

10 48%

Decreased haematocrit

10 48%

9 43%

7 33%

6 29%

5 24%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Ketoconazole cause decreased packed cell volume (pcv) in dogs?: 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 111 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased packed cell volume (pcv) with similar medicines

Decreased packed cell volume (pcv) after Melarsomine (Immiticide) 30 reports · 0.1% of its reports
Decreased packed cell volume (pcv) after Polysulfated Glycosaminoglycan 46 reports · 0.8% of its reports
Decreased packed cell volume (pcv) after Diphenhydramine 58 reports · 1.2% of its reports
Decreased packed cell volume (pcv) after Butorphanol 25 reports · 0.6% of its reports
Decreased packed cell volume (pcv) after Cefpodoxime 34 reports · 0.8% of its reports
Decreased packed cell volume (pcv) after Tramadol 50 reports · 1.3% of its reports
Decreased packed cell volume (pcv) after Desoxycorticosterone Pivalate 37 reports · 1.1% of its reports
Decreased packed cell volume (pcv) after Famotidine 53 reports · 2.0% of its reports
Decreased packed cell volume (pcv) after Chondroitin + Glucosamine 24 reports · 0.9% of its reports
Decreased packed cell volume (pcv) after Sucralfate 37 reports · 3.8% of its reports

All reported side effects of Ketoconazole in dogs · Medicines most reported with decreased packed cell volume (pcv)