Liver problems after Ketoconazole in dogs

The FDA has received 151 reports of liver problems in dogs after Ketoconazole. That is 6.7% of all reports for this medicine, compared with 4.6% across reports for all dog medicines.

151Reports
59%Marked serious
7.3%Recovered
26%Died or euthanised
34 daysTypical onset
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How soon it started

Same day
5 4.8%
1–2 days
7 6.7%
3–7 days
8 7.6%
1–4 weeks
28 27%
Over a month
57 54%

How the animals did

Recovered
6 4.0%
Recovered with lasting effects
5 3.3%
Still unwell when reported
71 47%
Died
21 14%
Euthanised
19 13%
Not known
29 19%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
16
4–7 years
50
8–11 years
59
12+ years
21

About this medicine

Type: medicine.

Questions owners ask

Can Ketoconazole cause liver problems in dogs?
151 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 34 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Ketoconazole in dogs · Medicines most reported with liver problems