Vocalising after Phenylpropanolamine (Proin) in dogs

The FDA has received 94 reports of vocalising in dogs after Phenylpropanolamine. That is 2.3% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

94Reports
54%Marked serious
48%Recovered
22%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
37 60%
1–2 days
10 16%
3–7 days
0 0.0%
1–4 weeks
5 8.1%
Over a month
10 16%

How the animals did

Recovered
44 47%
Recovered with lasting effects
1 1.1%
Still unwell when reported
6 6.4%
Died
11 12%
Euthanised
10 11%
Not known
22 23%

Problems reported at the same time

Age of the animals

Under 1 year
8
1–3 years
13
4–7 years
21
8–11 years
18
12+ years
34

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause vocalising in dogs?
94 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with vocalising