Vocalising after Trilostane (Vetoryl) in dogs

The FDA has received 140 reports of vocalising in dogs after Trilostane. That is 1.2% of all reports for this medicine, compared with 1.2% across reports for all dog medicines.

140Reports

60%Marked serious

23%Recovered

21%Died or euthanised

40 daysTypical onset

How soon it started

Same day

7 6.6%

1–2 days

3 2.8%

3–7 days

16 15%

1–4 weeks

19 18%

Over a month

61 58%

How the animals did

Recovered

32 23%

Still unwell when reported

20 14%

Died

11 7.9%

Euthanised

19 14%

Not known

58 41%

Problems reported at the same time

42 30%

39 28%

35 25%

31 22%

30 21%

27 19%

26 19%

20 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause vocalising in dogs?: 140 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 40 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Insulin 94 reports · 1.3% of its reports
Vocalising after Phenylpropanolamine (Proin) 94 reports · 2.3% of its reports
Vocalising after Levothyroxine 46 reports · 1.5% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with vocalising