Pain after Phenylpropanolamine (Proin) in dogs

28 reports to the FDA describe pain in dogs given Phenylpropanolamine. That is 0.7% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

28Reports

71%Marked serious

46%Recovered

36%Died or euthanised

19 daysTypical onset

How soon it started

Same day

6 32%

1–2 days

2 11%

3–7 days

1 5.3%

1–4 weeks

2 11%

Over a month

8 42%

How the animals did

Recovered

12 43%

Recovered with lasting effects

1 3.6%

Still unwell when reported

2 7.1%

Died

2 7.1%

Euthanised

8 29%

Not known

3 11%

Problems reported at the same time

11 39%

10 36%

10 36%

9 32%

9 32%

Restlessness or agitation

6 21%

Collapse

6 21%

Uncomfortable

5 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause pain in dogs?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pain with similar medicines

Pain after Trilostane (Vetoryl) 108 reports · 0.9% of its reports
Pain after Insulin 43 reports · 0.6% of its reports
Pain after Levothyroxine 28 reports · 0.9% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with pain