Collapse after Phenylpropanolamine (Proin) in dogs

65 reports to the FDA describe collapse in dogs given Phenylpropanolamine. That is 1.6% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

65Reports

77%Marked serious

26%Recovered

45%Died or euthanised

6 daysTypical onset

How soon it started

Same day

10 25%

1–2 days

9 23%

3–7 days

4 10%

1–4 weeks

4 10%

Over a month

13 33%

How the animals did

Recovered

16 25%

Recovered with lasting effects

1 1.5%

Still unwell when reported

11 17%

Died

16 25%

Euthanised

13 20%

Not known

8 12%

Problems reported at the same time

29 45%

18 28%

17 26%

16 25%

14 22%

13 20%

13 20%

11 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause collapse in dogs?: 65 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Trilostane (Vetoryl) 218 reports · 1.8% of its reports
Collapse after Insulin 81 reports · 1.1% of its reports
Collapse after Levothyroxine 44 reports · 1.5% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with collapse